an adjuvant and
an amyloid

First posted online: 3 October 2022

I am now increasingly concerned that COVID-19 mRNA "vaccines" create the perfect storm for vaccinal spike-induced amyloidogenesis due to certain biotechnology hacks. Such reckless administration of the genetic code of a lab-confirmed amyloid is egregious beyond all measure.

Rather than merely helping to form stable electrostatic complexes with the negatively charged mRNA and aiding its subsequent endosomal escape, the mRNA-LNP platform is highly inflammatory precisely due to its ionisable cationic lipid, not unlike a very potent adjuvant!! (1)

The transient rise in neutrophils observed on Day 2 post-injection (2) further suggests neutrophil-mediated innate immune activation, regardless of purported attempts via pseudouridylation to evade TLR7/8 innate immune sensing (3) and subsequent Type I interferon secretion. (4)

The recruitment of neutrophils could be expected to induce secretion of its serine protease enzyme, neutrophil elastase. In the presence of spike protein, this has been demonstrated, in vitro, to form highly amyloidogenic spike peptides. (5)

The pathological mechanism of action is vaccinal spike protein fibrils, following cleavage by neutrophil elastase, interfering with natural fibrin clot formation (under the action of thrombin), leading to plasmin-resistant clots that do not break down when no longer needed. (5)

As compared to replicating virus, a single LNP dose is administered all at once. The spike protein nucleotide sequence is codon optimised, thought to increase translation elongation speed. (6) So both the anti-LNP neutrophil activation and spike synthesis speed may be dramatic!

The trend of sudden unexplained deaths, including in younger age groups, and unusual clots reported by embalmers raises yet further concerns that vaccine-induced amyloidosis may be silently killing people. A full moratorium on all COVID-19 "vaccines" is long overdue.

Administration of LNPs is highly inflammatory in mice due to presence of ionisable cationic lipid

Neutrophils secrete enzyme neutrophil elastase, capable of cleaving spike protein into potently amyloidogenic peptides


  1. Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igyártó BZ. The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. iScience. 2021;24(12):103479. doi:10.1016/j.isci.2021.103479

  2. Sahin U, Muik A, Vogler I, et al. BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans. Nature. 2021;595(7868):572-577. doi:10.1038/s41586-021-03653-6

  3. Committee for Medicinal Products for Human Use, European Medicines Agency. Comirnaty Assessment Report. Published February 19, 2021. Accessed October 3, 2022.

  4. Uematsu S, Akira S. Toll-like receptors and Type I interferons. J Biol Chem. 2007;282(21):15319-15323. doi:10.1074/jbc.R700009200

  5. Nyström S, Hammarström P. Amyloidogenesis of SARS-CoV-2 Spike Protein. J Am Chem Soc. 2022;144(20):8945-8950. doi:10.1021/jacs.2c03925

  6. Lyu X, Yang Q, Zhao F, Liu Y. Codon usage and protein length-dependent feedback from translation elongation regulates translation initiation and elongation speed. Nucleic Acids Res. 2021;49(16):9404-9423. doi:10.1093/nar/gkab729